Beilstein J. Org. Chem.2020,16, 337–350, doi:10.3762/bjoc.16.33
DNA-photocleavers, and are proposed as new leads for “on demand” biotechnological applications in drug discovery and medicine.
Keywords: DNA binding; DNA photocleavage; N–O homolysis; oximecarbamates; photocleavage agents; Introduction
Small organic molecules able to bind DNA provide promises for
radicals are also produced from 2-(1-naphthylmethyl)imidazoline [35], whereas acylaminyl radicals [R(COR)N∙] are formed from the photocleavage of the N–O bond of N,O-diacyl-N-phenylhydroxylamines, along with a carbonyloxyl radical [38].
The photochemistry of O-carbamoyl oximes (or oximecarbamates) is well
studied. These compounds are categorized as highly photoreactive photobase generators (PBGs), providing amines upon rapid decarboxylation of the initially formed carbamoyloxyl radicals (R2NCOO∙) [49][50][51][52][53]. To the best of our knowledge oximecarbamates have never been photocleaved in the
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Graphical Abstract
Figure 1:
General structures of oxime derivatives with possible DNA photocleavage ability. Left: Oxime carbox...